Peer-reviewed veterinary case report
Dog with kidney disease and low aldosterone treated with DOCP
By Su-Min Park et al.·Published in Veterinary Medicine and Science·2022·View original on Semantic Scholar →
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Original publication title: Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism
- Species:
- dog
Plain-English summary
A 13-year-old spayed female Schnauzer with chronic kidney disease was brought in due to an electrolyte imbalance, showing high potassium and low sodium levels. After tests, the vet diagnosed her with isolated hypoaldosteronism, meaning her body wasn't producing enough aldosterone, a hormone that helps regulate electrolytes. The dog was treated with deoxycorticosterone pivalate (DOCP), which successfully corrected her electrolyte levels. This case is significant as it demonstrates a new way to manage this condition in dogs with chronic kidney disease and other health issues.
People also search for: dog electrolyte imbalance treatment · Schnauzer kidney disease · hypoaldosteronism in dogs
Abstract
Abstract A 13‐year‐old spayed female Schnauzer dog with chronic kidney disease (CKD; International Renal Interest Society stage 2, non‐proteinuric, normotensive), diabetes mellitus, hypercortisolism and myxomatous mitral valve degeneration (American College of Veterinary Internal Medicine stage B2) presented with electrolyte imbalance that had progressed to hyperkalaemia and hyponatremia, with a sodium to potassium (Na:K) ratio of 19.6. Cortisol levels after the adrenocorticotropic hormone stimulation test were within the therapeutic range, but aldosterone levels were below the reference range; hence, isolated hypoaldosteronism was diagnosed. After administration of deoxycorticosterone pivalate (DOCP), the electrolyte imbalance improved with a Na:K ratio of 27.7. This is the first report of the management of isolated hypoaldosteronism and hypercortisolism using trilostane and DOCP in a dog. This case highlights the importance of recognizing isolated hypoaldosteronism after long‐term treatment with trilostane in a canine patient with CKD.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/36106511