Peer-reviewed veterinary case report
Isolation, Characterization, and Possible Anti-Alzheimer's Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa.
- Journal:
- Chemistry & biodiversity
- Year:
- 2020
- Authors:
- Wu, Pei-Qian et al.
- Affiliation:
- School of Pharmacy · China
Abstract
One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32154990/