Peer-reviewed veterinary case report
Generalized mycobacteriosis in a dog and antibiotic testing
By Marianelli, Cinzia et al.·Published in Frontiers in veterinary science·2020·Department of Food Safety, Italy·View original on PubMed →
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Original publication title: Isolation, Molecular Typing, and Antibiotic Susceptibility Testing ofSubspeciesFrom a Dog With Generalized Mycobacteriosis.
- Species:
- dog
Plain-English summary
A crossbred dog was diagnosed with a rare and serious infection called generalized mycobacteriosis, which is caused by mycobacteria. The vet took a sample from a lymph node and found the bacteria, then tested different antibiotics to find the best treatment. Unfortunately, despite receiving appropriate therapy, the dog's condition continued to decline, and it sadly passed away eight months later. This case highlights the challenges of treating complex infections in pets.
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Abstract
complex infections are becoming an increasing concern in veterinary medicine because they affect livestock, wildlife, and companion animals. Here we describe the isolation, molecular typing, and antibiotic susceptibility testing of the causative agent of a rare case of generalized mycobacteriosis in a crossbred dog. Mycobacterial colonies were isolated from a popliteal lymph node aspirate sample and molecular typed by SNPs typing of the genesand, the 3' region of thegene and the internal transcribed spacer (ITS), and MIRU-VNTR analysis. Colonies were also testedagainst the macrolide clarithromycin and other drugs, using a resazurin microdilution assay, in order to provide the most appropriate treatment for the dog. Results from SNPs typing ofand ITS, as well as from MIRU-VNTR analysis suggested the isolation of a single strain ofsubsp.(Mah). On the other hand, SNP typing ofrevealed DNA polymorphisms that led colonies to cluster into two groups. The presence of two distinct strains of Mah has been assumed. All colonies, regardless of the nucleotide sequence of, were found to be sensitive to all of the drugs tested except for ethambutol. Although the therapy administered was adequate, the dog's overall clinical status worsened progressively and the animal died 8 months later. In conclusion, we report on the isolation of Mah from a dog with generalized mycobacteriosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33330691/