Peer-reviewed veterinary case report
Radiation treatment success for cat nasal and eye skin cancer
By Melzer, Katja et al.·Published in Journal of veterinary internal medicine·2006·Vetsuisse-Faculty·View original on PubMed →
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Original publication title: Ki67 reactivity in nasal and periocular squamous cell carcinomas in cats treated with electron beam radiation therapy.
- Species:
- cat
Plain-English summary
Seventeen cats with squamous cell carcinoma, a type of skin cancer common in cats with less fur, were treated with a specialized radiation therapy called electron beam radiation. Most of the cats responded very well to the treatment, with a 94% complete response rate, meaning their tumors shrank significantly or disappeared. The average time before the cancer returned was about 414 days, and side effects were mostly mild and manageable. Cats with tumors that showed more aggressive growth (high Ki67 reactivity) had better outcomes with this treatment.
People also search for: cat skin cancer treatment · squamous cell carcinoma in cats · electron beam radiation for cats
Abstract
Squamous cell carcinomas of sparsely haired skin are relatively common tumors in cats, and these tumors likely exhibit a rapid growth rate. Thus, we evaluated response and duration of response in relation to the Ki67 proliferative reactivity in such tumors. Seventeen cats with confirmed squamous cell carcinomas and treated with an accelerated, hypofractionated electron beam radiation protocol were included in the study. For all of them histologic grading, Ki67 reactivity, response, and disease-free interval (DFI) were evaluated. Response to therapy was excellent (94% complete response rate) with a median DFI of 414 days. Only moderate acute and few long-term adverse effects were seen. Cats with tumors with a low Ki67 reactivity had markedly shorter DFIs than cats with tumors with high Ki67 reactivity. We concluded that an accelerated, hypofractionated electron beam radiation therapy protocol is well suited for feline squamous cell carcinomas. The protocol appears especially efficacious in tumors with a high Ki67 reactivity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16734107/