Peer-reviewed veterinary case report
Seizures and tremors in South African Staffordshire Bull Terrier
By Böhm, Marlies et al.·Published in Journal of the South African Veterinary Association·2014·King Edward Veterinary Referral Hospital. marlies@wol.co.za.·View original on PubMed →
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Original publication title: L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier.
- Species:
- dog
Plain-English summary
A 3-year-old South African Staffordshire Bull Terrier was brought in for seizures and tremors, which are signs of a metabolic disorder called L-2 hydroxyglutaric aciduria. This condition can also cause issues like ataxia (loss of coordination) and behavioral changes. The dog underwent various tests, including genetic testing, to confirm the diagnosis. While there is no specific treatment for this condition, understanding it can help veterinarians identify affected dogs and manage their symptoms better.
People also search for: Staffordshire Bull Terrier seizures · dog metabolic disorder symptoms · L-2 hydroxyglutaric aciduria treatment
Abstract
L-2 hydroxyglutaric aciduria is an autosomal recessive error of metabolism that manifests as an encephalopathy. The most common presenting signs are seizures, tremors, ataxia and/ or dementia. Some affected dogs show only subtle behavioural changes. Amongst canines, the condition has been best described in Staffordshire Bull Terriers. Although this is the first reported case in South Africa, at least three other affected dogs have been indentified by polmerase chain reaction (PCR) in this country. Affected dogs have normal haematology, serum biochemistry and routine urine analysis. This report discusses the advantages and limitations of the three main diagnostic modalities, namely: magnetic resonance imaging, urine gas chromatography-mass spectrometry and genetic testing. The aim of this report is to increase awareness of the condition, assist diagnosis in encephalopathic dogs and improve detection of carriers amongst breeding stock.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24830757/