Peer-reviewed veterinary case report
L-LOP and L-LOPP chemo for dog gut and liver lymphoma
By Lai, Yu Ying et al.·Published in Frontiers in Veterinary Science·2024·View original on Crossref →
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Original publication title: L-LOP/LOPP for the treatment of canine gastrointestinal/hepatosplenic lymphoma
- Species:
- dog
Plain-English summary
A dog diagnosed with gastrointestinal lymphoma was treated with a new chemotherapy protocol that included lomustine and other medications. This treatment was generally well tolerated, with only a few serious side effects reported. On average, dogs with gastrointestinal lymphoma lived for about 93 days after starting treatment, while those with hepatosplenic lymphoma had a median survival of 210 days. Although these lymphomas are challenging to treat, this new approach showed some promise in extending survival times for affected dogs.
People also search for: dog lymphoma treatment · gastrointestinal lymphoma in dogs · chemotherapy for dog cancer
Abstract
Canine gastrointestinal (GI) and hepatosplenic (HS) high-grade (large cell) lymphomas are uncommon forms of canine lymphomas, with a very poor response to chemotherapy and a very poor prognosis. Currently, there are no established effective chemotherapy protocols for canine GI/HS lymphomas. This case series aimed to retrospectively evaluate the efficacy of lomustine-based protocols L-LOP (L-asparaginase, lomustine, vincristine, and prednisolone) and L-LOPP (with the addition of procarbazine) for treatment of canine GI/HS lymphomas. Medical records of dogs with cytologically or histologically diagnosed lymphoma at CityU Veterinary Medical Centre from 2019 to 2022 were retrospectively reviewed. The L-LOP/LOPP treatment protocol was well tolerated with rare severe adverse events. Median progression-free survival for GI and HS lymphoma was 56 days (range, 10–274 days) and 57 days (range 8–135 days) respectively; while median survival time for GI and HS lymphoma was 93 days (range 10–325 days) and 210 days (range 8–240 days) respectively.
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Search related cases →Original publication on Crossref: https://doi.org/10.3389/fvets.2024.1373180