Peer-reviewed veterinary case report
Angiogenesis does not predict outcome in dog melanocytic tumors
By Cuitiño, M C et al.·Published in Journal of comparative pathology·2012·Laboratorio de Patologí·View original on PubMed →
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Original publication title: Lack of prognostic significance of angiogenesis in canine melanocytic tumours.
- Species:
- dog
Plain-English summary
A study looked at different types of skin tumors in dogs, specifically focusing on melanocytic tumors, which can be benign or malignant. Researchers found that while malignant melanomas had more blood vessels than benign melanocytomas, this increased vascularization did not help predict how long the dogs would survive after diagnosis. This means that even though the tumors with more blood vessels were more aggressive, the number of blood vessels didn't provide useful information about the dog's prognosis. Overall, the findings suggest that other factors should be considered when evaluating these tumors in dogs.
People also search for: dog melanoma prognosis · canine skin tumors treatment · what to expect with dog melanocytoma
Abstract
The prognostic significance of angiogenesis in some canine tumours has been investigated, but little is known about its relevance in canine melanocytic tumours (MTs). The aim of this study was to evaluate the prognostic significance of angiogenesis in canine MTs. A total of 36 cutaneous melanocytomas (benign MTs), 40 cutaneous melanomas (malignant MTs) and 43 oral melanomas were studied. Survival data were available for a subset of 59 cases. Microvessel density (MVD) and endothelial area (EA) were determined by immunolabelling using an antibody specific for von Willebrand factor (vWF). Mean MVD (expressed as the number of microvessels per mm(2)) was 129 ± 14 in melanocytomas, 191 ± 16 in cutaneous melanomas and 208 ± 16 in oral melanomas. Mean EA (expressed as the percentage of the total area) was 1.5 ± 0.14 in melanocytomas, 2.6 ± 0.2 in cutaneous melanomas and 2.4 ± 0.3 in oral melanomas. The differences in MVD and EA between melanocytomas and melanomas were significant (P = 0.001 and P = 0.003, respectively). MVD and EA were significantly correlated between cutaneous and oral MTs (r = 0.54; P <0.001 and r = 0.63; P <0.001, respectively). MVD and EA were not related to survival in cutaneous and oral MTs. In conclusion, tumour vascularization was higher in melanomas than in melanocytomas, but it seemed to have no prognostic significance in these tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22520819/