Peer-reviewed veterinary case report
Dog with spinal lymphoma and high eosinophils in spinal fluid
By Massie, Anna M et al.·Published in Journal of veterinary internal medicine·2023·Department of Clinical Sciences and Advanced Medicine, United States·View original on PubMed →
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Original publication title: Large T-cell extradural lymphoma with concurrent marked cerebrospinal fluid eosinophilia in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old male pit bull was brought in because he was having trouble moving all four legs and had neck pain for four days. An MRI showed a mass in his spine, and tests of his spinal fluid revealed a high level of eosinophils, which are a type of white blood cell often linked to allergic reactions or infections. The vet performed surgery to remove part of the mass and started chemotherapy, which helped the dog improve and live for over three years before he was sadly euthanized due to complications from other health issues. This case shows that dogs with this type of lymphoma can respond well to treatment.
People also search for: dog neck pain · pit bull lymphoma treatment · dog spinal surgery recovery
Abstract
A 3-year-old male pit bull terrier was presented for a 4-day history of progressive tetraparesis and cervical pain. Magnetic resonance imaging confirmed an extradural mass within the left lateral vertebral canal extending from caudal C5 to mid-T2. Lumbar cerebrospinal fluid (CSF) demonstrated marked (90%) eosinophilic inflammation. A C6-7 dorsal laminectomy and C7-T2 left hemilaminectomy were done, with gross disease remaining. Histopathology revealed a large T cell lymphoma with marked eosinophilic infiltration. The dog underwent CHOP-based chemotherapy with resolution of clinical signs, with a similar course of therapy performed at recurrence 37 months after initial presentation. The dog was euthanized 39 months after presentation for multiorgan failure secondary to neutropenic sepsis and aspiration pneumonia. This represents a positive long-term response to multimodal treatment of extradural T-cell lymphoma within the vertebral canal associated with a marked CSF eosinophilia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37849352/