Peer-reviewed veterinary case report
LaSap vaccine and allopurinol treatment for dogs with Leishmania
By Clasta, Ricardo B et al.·Published in Parasite immunology·2024·Latin American Institute of Life and Nature Sciences, Brazil·View original on PubMed →
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Original publication title: LaSap vaccine: Immunotherapy and immunochemotherapy associated with allopurinol in dogs naturally infected with Leishmania infantum.
- Species:
- dog
Plain-English summary
A group of 44 dogs with symptoms of leishmaniasis, a disease caused by a parasite, were treated with either a vaccine called LaSap or the vaccine combined with allopurinol, a medication that helps manage the disease. After 90 days, both treatment methods showed significant improvement in the dogs' health, particularly in reducing the parasite load in the skin. However, the dogs that received only the vaccine maintained their health improvements without needing additional medication. This suggests that the LaSap vaccine is an effective option for managing leishmaniasis in dogs.
People also search for: dog leishmaniasis treatment · LaSap vaccine for dogs · allopurinol for dog parasites
Abstract
Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty-four symptomatic and naturally infected dogs with Leishmania infantum were tested with two treatment protocols (i) immunotherapy with LaSap vaccine and (ii) immunochemotherapy with LaSap vaccine plus allopurinol. At 90 days after the end of the treatment, it was verified that, although both protocols had generated significant clinical improvements with a greater production of IFN-γ/IL-10, in relation to the parasite load, mainly in the skin, the dogs treated only with immunotherapy maintained the same profile. These results indicate that LaSap is a good strategy to control dog parasitism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38389494/