Peer-reviewed veterinary case report
Leukocytes entering the brain in dogs with Leishmania infection
By Melo, G D et al.·Published in Veterinary parasitology·2009·UNESP-FO-Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Leukocyte entry into the CNS of Leishmania chagasi naturally infected dogs.
- Species:
- dog
Plain-English summary
A group of mixed-breed dogs with chronic leishmaniasis (a disease caused by a parasite) showed signs of neurological problems, such as changes in behavior or coordination. Researchers found that these dogs had a significant increase in certain immune cells in their brains, indicating inflammation. The cerebrospinal fluid (the fluid surrounding the brain and spinal cord) of the infected dogs contained high levels of antibodies against the parasite, suggesting that the disease was affecting the brain's protective barriers. This study highlights the link between leishmaniasis and neurological issues in dogs, emphasizing the need for careful monitoring and treatment of affected pets.
People also search for: dog leishmaniasis symptoms · dog neurological problems treatment · mixed-breed dog brain inflammation
Abstract
In dogs, there is an association of chronic visceral leishmaniasis with neurological symptoms, and very few publications have investigated whether these neurological manifestations correlate with specific alterations in brain. A total of 42 mixed-breed adult dogs were selected from the Veterinary Hospital of UNESP-Araçatuba and the Control Zoonosis Center in Araçatuba, São Paulo State, Brazil, which is an endemic area for visceral leishmaniasis. Animals presenting positive ELISA and/or positive parasitological diagnosis of Leishmania were enrolled in the group of infected dogs (n=32). Animals with negative ELISA results and parasitological tests for Leishmania, including a negative immunofluorescence test for toxoplasmosis and neosporosis, were included as the control group (n=10). Brain samples were collected, stored in 10% buffered formalin and subjected to routine histological procedures, following by staining with haematoxylin-eosin (HE) and immunohistochemical examination for T and B lymphocytes and phagocytic cells. Cerebrospinal fluid was collected to determine the anti-Leishmania antibody titers. Histological examination of HE stains demonstrated intense inflammatory infiltrate, primarily in the choroid plexus, which was composed of mononuclear cells with no detectable parasites. Immunohistochemistry revealed that CD3(+) T lymphocytes were the major components of the inflammatory infiltrate at the choroid plexus and in the brain. Infected dogs had more CD3(+) T cells than uninfected animals (P=0.0002). Cerebrospinal fluid from infected dogs contained high titers of anti-Leishmania antibodies in comparison with control animals (P<0.0001), which suggests a compromise of the blood-cerebrospinal fluid barrier. Leukocyte entry into the brain suggests the participation of these cells in the pathogenesis of neurological disorders during the advanced stages of leishmaniasis and confirms that the choroid plexus is an important structure for T cell influx.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19362424/