Peer-reviewed veterinary case report
Genetic link to dermatomyositis in Shetland Sheepdogs on chromosome 35
By Clark, Leigh Anne et al.·Published in Veterinary dermatology·2005·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35.
- Species:
- dog
Plain-English summary
A Shetland Sheepdog with skin and muscle inflammation, known as dermatomyositis, can show a variety of symptoms, making it hard to diagnose early. Researchers have identified a specific genetic marker linked to this condition on chromosome 35, which could help develop a DNA test for early detection in affected dogs. This discovery is a step toward better understanding and managing dermatomyositis in Shetland Sheepdogs. Further studies are needed to pinpoint the exact genes involved and how the disease is inherited.
People also search for: Shetland Sheepdog skin problems · dermatomyositis in dogs · dog genetic testing for skin disease
Abstract
Dermatomyositis is an inflammatory disease of the skin and muscle and is most commonly found in the Shetland sheepdog. Both the clinical presentation and the age of onset of dermatomyositis vary widely, and the inability to diagnose dermatomyositis before clinical symptoms ensue has made control of the disease difficult. Identification of a genetic marker that cosegregates with dermatomyositis would facilitate the development of a DNA-based test for the early detection of affected dogs. We report the use of linkage disequilibrium (LD) mapping to identify linkage to phenotypic dermatomyositis in the Shetland sheepdog. One marker, microsatellite marker FH3570 on canine chromosome 35, had evidence of LD (P=0.00002). Further studies are necessary to narrow the region harbouring the dermatomyositis locus, identify candidate genes and determine mode of inheritance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16359306/