Peer-reviewed veterinary case report
Dog treated with local carboplatin after ulnar bone cancer surgery
By Risselada, Marije et al.·Published in Journal of the American Animal Hospital Association·2020·From the Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog.
- Species:
- dog
Plain-English summary
An 8-year-old male hound was diagnosed with an osteosarcoma (a type of bone cancer) in his left front leg. After confirming that the cancer hadn't spread, the veterinarian performed surgery to remove the affected bone and used a special gel to deliver a chemotherapy drug directly to the area. The dog recovered well from the surgery without any complications, and there were no issues with healing. He remained free of cancer recurrence for nearly 10 months after the procedure and lived for about 15 months after his initial diagnosis.
People also search for: dog osteosarcoma treatment · hound bone cancer surgery · local chemotherapy for dogs
Abstract
An 8 yr old male castrated hound presented for a left distal ulnar osteosarcoma. Staging (computed tomography and nuclear scintigraphy) did not reveal any metastases. A limb-sparing ulnectomy with local adjunctive carboplatin in a poloxamer copolymer gel (poloxamer 407) was performed. The patient recovered without complications after surgery. No wound healing complications or adverse effects occurred after local use of carboplatin in poloxamer 407. The local recurrence-free interval was 296 days from surgery, and the survival time was 445 days from initial diagnosis. This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33113558/