Peer-reviewed veterinary case report
Dog with anal melanoma treated by electrochemotherapy to ease
By Spugnini, Enrico P et al.·Published in In vivo (Athens, Greece)·2007·Centre of Biomedical Engineering Ivan Daskalov·View original on PubMed →
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Original publication title: Local control and distant metastasis after electrochemotherapy of a canine anal melanoma.
- Species:
- dog
Plain-English summary
A 10-year-old dog with anal melanoma was brought in because he was having trouble defecating. The vet used a treatment called electrochemotherapy, which involved delivering a chemotherapy drug directly into the tumor using electrical pulses. This treatment successfully shrank the tumor and allowed the dog to have normal bowel movements for three months. Unfortunately, the cancer later spread to his lymph nodes, causing an intestinal blockage, and he had to be euthanized. While the treatment helped temporarily, the aggressive nature of the cancer ultimately led to a poor outcome.
People also search for: dog anal melanoma treatment · why is my dog constipated · electrochemotherapy for dogs
Abstract
Canine anal melanoma is an aggressive neoplasm that rapidly leads to constipation in dogs, thus mimicking the behavior of their human counterpart. In this paper, the successful local palliation of this neoplasm is described using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction with restoration of normal defecation for three months, then experienced massive dissemination to the sublumbar lymph nodes that led to intestinal obstruction and euthanasia. Electrochemotherapy (ECT) is a safe palliative therapy for such neoplasm and warrants further investigations in dogs as well humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18019432/