Peer-reviewed veterinary case report
Localization of transforming growth factor beta3 in squamous metaplasia of the porcine oviduct: a case report.
- Journal:
- Reproduction in domestic animals = Zuchthygiene
- Year:
- 2010
- Authors:
- Steffl, M et al.
- Affiliation:
- Department of Anatomy and Physiology of Domestic Animals · Germany
Abstract
Squamous metaplasia of the oviduct epithelium is a rare disorder of reproductive organs. We noted squamous metaplasia of the oviduct epithelium in a sow routinely slaughtered at day 2 of the oestrous cycle. Expression of transforming growth factor beta3 (TGF beta3) in the metaplastic epithelia was evaluated by immunohistochemistry, because TGF beta3 appears to play a key role as regulator of a variety of tissue remodelling events. Our results show that TGF beta3 immunostaining was specifically localized to foci of squamous metaplasia of the epithelial linings. Non-metaplastic epithelial cells of the oviduct were not immunostained with anti-TGF beta3 antibody. At the subcellular level, TGF beta3-labelled cells occasionally showed signs of apoptotic cell death. It is concluded that signals produced by TGF beta3 in metaplastic lesions of the oviduct are potentially involved in pathophysiological processes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19144038/