Peer-reviewed veterinary case report
Lokivetmab helped reduce itching in a dog with skin lymphoma
By Inai, Kiyohiko et al.·Published in The Journal of veterinary medical science·2022·Sakura Animal Hospital, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Lokivetmab improved pruritus in a dog with cutaneous epitheliotropic lymphoma.
- Species:
- dog
Plain-English summary
A 13-year-old spayed female Cavalier King Charles Spaniel was suffering from severe itching and swelling on her paw and tail due to a skin cancer called cutaneous epitheliotropic lymphoma (CEL). Initially, she was treated with a steroid medication called prednisolone, but her symptoms continued to worsen. To help with the itching, the vet added a new treatment called lokivetmab, which targets a specific protein involved in itching. After starting lokivetmab, her itching improved significantly, and she was able to maintain a better quality of life.
People also search for: dog itching treatment · Cavalier King Charles Spaniel skin cancer · lokivetmab for dog pruritus
Abstract
A 13-year-old spayed female Cavalier King Charles Spaniel presented with chronic swelling and pruritus on the palmar aspect of the left forepaw and on the tail. Cutaneous epitheliotropic lymphoma (CEL) was diagnosed by histopathology and immunocytochemistry. Prednisolone was initially used alone as an alternative treatment for CEL. Despite long-term corticosteroid therapy, the patient's physiological (pruritus) and dermatological signs (alopecia, erythema, erosion, and ulceration with crust) progressed and showed no evidence of improvement. To address the worsening condition of pruritus, lokivetmab was started in combination with prednisolone. Once on lokivetmab, the pruritus steadily improved and was effective in resolving and maintaining remission. Further investigation on the critical role of IL-31 in the pruritus pathway of dogs with CEL is required.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34866072/