Peer-reviewed veterinary case report
Dog's lymphoma progressed from nodal marginal zone to large B-cell
By Shiga, Takanori et al.·Published in Veterinary pathology·2020·The University of Tokyo, Japan·View original on PubMed →
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Original publication title: Long-Term Observation of the Progression From Nodal Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma in a Dog.
- Species:
- dog
Plain-English summary
A 4-year-old female Pembroke Welsh Corgi was brought to the vet with a swollen lymph node behind her knee. She was diagnosed with a type of lymphoma called nodal marginal zone lymphoma and had the lymph node surgically removed. After a period of observation without chemotherapy, her condition worsened, and she developed more swollen lymph nodes. Chemotherapy helped her go into remission twice, but unfortunately, the cancer returned each time. Sadly, she passed away nearly five years after her initial diagnosis, and further tests showed that her lymphoma had progressed to a more aggressive form called diffuse large B-cell lymphoma.
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Abstract
A 4-year and 10-month old female Pembroke Welsh Corgi presented with an enlarged right popliteal lymph node, and a histopathological diagnosis of nodal marginal zone lymphoma (nMZL) was made. After resection of the lymph node, follow-up observation was continued without chemotherapy. At 22 months after initial presentation, the dog developed enlargement of peripheral lymph nodes, and the histopathological diagnosis was late-stage nMZL. Multidrug chemotherapy induced clinical complete remission, but the tumor relapsed with enlargement of peripheral and abdominal lymph nodes 42 months after initial presentation. Second-round multidrug chemotherapy induced complete clinical remission again; however, the tumor relapsed with lymphadenopathy 47 months after initial presentation. The dog died 59 months after initial presentation, and postmortem examination revealed generalized lymphadenopathy; the histopathological diagnosis was diffuse large B-cell lymphoma (DLBCL). Polymerase chain reaction for antigen receptor gene rearrangements revealed that the nMZL and DLBCL samples were derived from the same B-lymphocyte clone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32608349/