Peer-reviewed veterinary case report
Long-term survival and kidney recovery in dogs after acute kidney
By Bar-Nathan, Mali et al.·Published in Journal of veterinary internal medicine·2022·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: Long-term outcome of dogs recovering from acute kidney injury: 132 cases.
- Species:
- dog
Plain-English summary
A group of 132 dogs that had acute kidney injury (AKI) were followed for their long-term recovery after being discharged from the vet. Most of these dogs, about 76%, were still alive more than three years later, and many showed improvement in their kidney function. While 55% had normal kidney blood levels when they left the vet, an additional 20% improved over time. Interestingly, how well they recovered wasn't directly linked to their long-term survival, but the cause of their kidney injury played a significant role in their overall outcome. Most dogs did better than expected, highlighting the potential for recovery after AKI.
People also search for: dog acute kidney injury recovery · dog kidney function improvement · long-term outcome for dogs with kidney disease
Abstract
BACKGROUND: Information regarding long-term outcome of dogs recovering from acute kidney injury (AKI) is limited. OBJECTIVES: Determine the long-term outcome of dogs recovering from AKI and identify predictors for serum creatinine concentration (sCr) normalization and long-term outcome. ANIMALS: One hundred thirty-two dogs with AKI that survived ≥30 days postdischarge. METHODS: Retrospective study. Search of medical records of dogs diagnosed with AKI that survived to discharge. Follow-up data were retrieved from medical records and by telephone interviews with the owners or primary care veterinarians or both. RESULTS: Estimated median survival time (MST) was 1322 days (95% confidence interval [CI], 1147-1626), and 76% of the dogs were alive at last contact. Normalization of sCr was documented in 55% of the dogs at discharge and in additional 20% during the follow-up period. The proportion of dogs with sCr normalization decreased with increase in AKI grade (P = .02). Long-term survival was not associated with sCr normalization (P = .63). Etiology was associated with the long-term outcome (P = .004). CONCLUSION AND CLINICAL IMPORTANCE: Long-term survival of dogs with AKI is longer than previously described. Normalization of sCr in 99 dogs (75%) occurred, either at discharge or within the follow-up period. Normalization of sCr was not associated with long-term survival. Estimated MST of dogs with sCr normalization was not different compared with dogs that developed azotemic chronic kidney disease (CKD), presumably because of slow CKD progression rate. Etiology is an important factor determining sCr normalization and long-term survival, emphasizing the importance of the reversibility of renal injury rather than its severity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35478193/