Peer-reviewed veterinary case report
Dog with brain tumor lived 2 years after radiation and chemo
By Hasegawa, Daisuke et al.·Published in The Journal of veterinary medical science·2012·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU.
- Species:
- dog
Plain-English summary
A 9-year-old neutered male French Bulldog was brought in for cluster seizures and diagnosed with a brain tumor called glioma. The dog received radiation therapy, which initially reduced the tumor size, but it came back a few months later. Chemotherapy with a drug called CCNU was started and continued for a year, which again helped shrink the tumor. Unfortunately, two years later, the dog experienced severe seizures and other neurological issues, and ultimately passed away.
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Abstract
A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2 months after RT, recurrence was observed at 4 months after RT. Chemotherapy was started using CCNU (60 mg/m(2) every 6-9 weeks) and was continued for one year. Follow-up MRI revealed involution of the lesion and the intervals of CCNU were increased to every 9-14 weeks. Two years after the first presentation, the dog suffered status epilepticus, followed by deficits of left sided postural reaction with cognitive dysfunction. The dog died on day 910, and histopathological diagnosis confirmed anaplastic oligodendroglioma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22785244/