Peer-reviewed veterinary case report
Dog with lupus anticoagulant causing anemia and blood clots
By Stone, M S et al.Ā·Published in Journal of veterinary internal medicineĀ·1994Ā·Department of Clinical Studies, CanadaĀ·View original on PubMed ā
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Original publication title: Lupus-type "anticoagulant" in a dog with hemolysis and thrombosis.
- Species:
- dog
Plain-English summary
A 2-year-old Chesapeake Bay Retriever was brought in with symptoms including anemia, low platelet count, and breathing difficulties due to blood clots in the lungs. Tests showed a persistent issue with blood clotting that did not improve with treatment using fresh frozen plasma. The dog was found to have a condition similar to lupus anticoagulant, which paradoxically increases the risk of blood clots despite being an anticoagulant. Unfortunately, this condition can complicate treatment, but recognizing it can help veterinarians manage the dog's symptoms more effectively.
People also search for: dog breathing problems blood clots Ā· Chesapeake Bay Retriever anemia treatment Ā· dog lupus anticoagulant symptoms
Abstract
A circulating anticoagulant was detected in a 2-year-old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not correct with repeated administration of fresh frozen plasma. The aPTT was still prolonged, with a 1:1 mixture of patient's plasma and normal dog plasma in vitro, suggesting the presence of a circulating inhibitor. Results of assays to characterize the inhibitor were compatible with those described for the lupus anticoagulant in human patients with systemic lupus erythematosus. Paradoxically, patients having the lupus anticoagulant are at increased risk for thrombosis. Pulmonary thromboembolism has been described as a frequent complication of immune-mediated hemolytic anemia in the dog, and the presence of a circulating anticoagulant should be considered as a potential mechanism.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8176665/