Peer-reviewed veterinary case report
Horse has a mass in the eye - what is lymphangiosarcoma?
By Puff, Christina et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2008·Department of Pathology, Germany·View original on PubMed →
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Original publication title: Lymphangiosarcoma in the nictitating membrane of a horse.
- Species:
- horse
Plain-English summary
A 15-year-old Haflinger gelding had a growth in the left nictitating membrane, which is a part of the eye. The horse underwent two biopsies and had the affected membrane surgically removed, but the mass came back. Unfortunately, due to the poor outlook after the mass reappeared, the horse was euthanized. The examination of the tissue showed that the mass was a type of cancer called lymphangiosarcoma, which affects the lymphatic vessels. The treatment did not work, leading to the decision to euthanize the horse.
Abstract
A 15-year-old Haflinger gelding presented with a mass in the left nictitating membrane. Two biopsies and the excised nictitating membrane were taken at different time points as a result of reoccurrence of the mass and submitted for histopathologic evaluation. The horse was euthanized as a result of poor prognosis following the reoccurrence of the mass after surgical removal. Histologically, the mass consisted of dilated, thin-walled vascular clefts and channels, lined by flattened to cuboidal endothelial cells with moderate cellular pleomorphism. There was up to 1 mitotic figure per high power field. The channels were empty or contained few erythrocytes. In the collagen-rich stroma, few lymphocytes, focal follicular lymphoid aggregations, and marked lymphangiectasia were observed. Immunohistochemically, the neoplastic cells stained positive for vimentin and partially positive for factor VIII-related antigen. Ultrastructural analysis revealed discontinuous endothelial lining vascular channels that partially lacked a basal membrane. Based on the histopathologic, immunohistochemical, and ultrastructural features lymphangiosarcoma was diagnosed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18182523/