Peer-reviewed veterinary case report
Dog with swollen lymph nodes and high lymphocyte count from two
By Long, Mackenzie E et al.·Published in Veterinary clinical pathology·2020·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: Lymphocytosis and lymphadenopathy in a dog arising from two distinct lymphoid neoplasms.
- Species:
- dog
Plain-English summary
A 10-year-old male Golden Retriever was taken to the vet for sudden swelling on the right side of his face, which turned out to be due to enlarged lymph nodes. Further tests showed that he had an increased number of white blood cells, particularly lymphocytes, indicating a possible cancer. The vet found two different types of abnormal lymphocytes in his blood and lymph nodes, one type related to T cells and another to B cells, confirming he had two distinct lymphoid cancers. Treatment options would depend on the specific diagnosis and staging, so it's important to discuss next steps with your veterinarian.
People also search for: dog facial swelling · Golden Retriever lymph node cancer · dog lymphocytosis treatment
Abstract
A 10-year-old intact male Golden Retriever was presented to The Ohio State University Veterinary Medical Center for acute, non-painful facial swelling of the right mandibular region. On physical examination, the right mandibular swelling was found to represent marked lymphadenopathy of the submandibular lymph node. At this time, marked lymphadenopathy of the prescapular and popliteal lymph nodes was also appreciated. The CBC showed a moderate leukocytosis (38.4 × 10cells/L, reference interval [RI] 4.8-13.9 × 10cells/L) characterized by a moderate lymphocytosis (28.4 × 10cells/L, RI 1.0-4.6 × 10cells/L). Evaluation of peripheral blood and enlarged prescapular and popliteal lymph nodes revealed two morphologically different populations of homogeneous lymphocytes, with the lymphocyte population in the lymph nodes being distinct from that in the blood smear. Flow cytometry of peripheral blood revealed CD45-, CD5+, CD4-, CD8-, variably CD21+ neoplastic lymphocytes compatible with T-zone lymphocytes due to the absence of CD45 expression. Flow cytometry of the lymph node aspirate indicated a distinct population of CD21+ lymphocytes consistent with a B-cell phenotype along with a smaller proportion of the T-zone lymphocytes observed in the blood confirming the presence of two distinct populations of neoplastic lymphocytes, one involving T cells, and the other involving B cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32347563/