Peer-reviewed veterinary case report
Genetic risk factors for lymphoma in Border Collies
By Soh, Pamela Xing Yi et al.·Published in Veterinary Sciences·2023·School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia, Australia·View original on Crossref →
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Original publication title: Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis
- Species:
- dog
Plain-English summary
A study looked at lymphoma, a common type of cancer, in Border Collies. Researchers analyzed the family trees of 83,000 Border Collies and found 71 cases of lymphoma, identifying a common ancestor for many of them. They also conducted a genetic study to find specific areas in the dogs' DNA that might be linked to the disease. The results pointed to certain genes that could be involved in the development of lymphoma in these dogs. This research could help in understanding the genetic risks for lymphoma in Border Collies and potentially guide future prevention and treatment strategies.
People also search for: Border Collie lymphoma symptoms · dog cancer genetics · lymphoma treatment for dogs
Abstract
There has been considerable interest in studying cancer in dogs and its potential as a model system for humans. One area of research has been the search for genetic risk variants in canine lymphoma, which is amongst the most common canine cancers. Previous studies have focused on a limited number of breeds, but none have included Border Collies. The aims of this study were to identify relationships between Border Collie lymphoma cases through an extensive pedigree investigation and to utilise relationship information to conduct genome-wide association study (GWAS) analyses to identify risk regions associated with lymphoma. The expanded pedigree analysis included 83,000 Border Collies, with 71 identified lymphoma cases. The analysis identified affected close relatives, and a common ancestor was identified for 54 cases. For the genomic study, a GWAS was designed to incorporate lymphoma cases, putative “carriers”, and controls. A case-control GWAS was also conducted as a comparison. Both analyses showed significant SNPs in regions on chromosomes 18 and 27. Putative top candidate genes from these regions included DLA-79, WNT10B, LMBR1L, KMT2D, and CCNT1.
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Search related cases →Original publication on Crossref: https://doi.org/10.3390/vetsci10090581