Peer-reviewed veterinary case report
Lymphosarcoma with leukemia in a horse.
- Journal:
- American journal of veterinary research
- Year:
- 1982
- Authors:
- Madewell, B R et al.
- Species:
- horse
Plain-English summary
A 17-year-old Arabian gelding was brought in because he was very tired and losing weight. During the exam, the vet found swollen lymph nodes, fluid buildup in his abdomen, and swelling in his legs. Tests on a sample from his lymph nodes and a blood count showed he had lymphosarcoma (a type of cancer affecting the lymphatic system) along with signs of leukemia (a blood cancer), with a high number of abnormal lymphocytes (a type of white blood cell) that weren't functioning properly. Unfortunately, the treatment details and outcome were not provided, so we can't say how he responded to any treatments.
Abstract
A 17-year-old Arabian gelding was presented because of CNS depression and weight loss. Physical examination revealed generalized lymphadenopathy, pitting edema, and ascites. The diagnosis of lymphosarcoma with leukemic manifestations was based on cytologic and histopathologic examination of lymph node biopsy samples and a peripheral leukocyte count of 98,300/microliters, 94% of which were mature lymphocytes. These circulating lymphocytes lacked B-lymphocyte markers and did not respond to mitogenic stimulation, indicating functional incompetence. Though ultrastructural findings were equivocal, most morphologic changes indicated these cells were of T-lymphocyte lineage. Virus particles were not observed during transmission electron microscopy of these lymphocytes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/6896410/