Peer-reviewed veterinary case report
Brain MRI and tissue findings in Standard Poodle puppy with neonatal
By Yu, Yoshihiko et al.·Published in Frontiers in veterinary science·2020·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
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Original publication title: Magnetic Resonance Imaging and Histopathologic Findings From a Standard Poodle With Neonatal Encephalopathy With Seizures.
- Species:
- dog
Plain-English summary
A 2-week-old Standard Poodle puppy was brought in for seizures and showed signs of neonatal encephalopathy, a serious brain condition. MRI scans revealed that the puppy's brain was smaller than normal, with abnormal fluid-filled spaces and developmental issues in the brain's white matter. The puppy's brain also had irregularities in neuron placement and other structural problems. Unfortunately, due to the severity of the condition, the prognosis was poor, and the puppy likely required specialized care.
People also search for: Standard Poodle puppy seizures · neonatal encephalopathy in dogs · puppy brain development issues
Abstract
Neonatal encephalopathy with seizures (NEwS) is an epileptic encephalopathy with an autosomal recessive inheritance pattern found in Standard Poodle puppies. The causal genetic variant for NEwS has been identified as a homozygous missense mutation in(c.152T>G, p.Met51Arg), and a pathological cerebellar change has been reported. Magnetic resonance imaging showed reduced whole-brain size, dilated ventricles, developmental abnormalities of the white matter of the cerebrum, white matter signal abnormalities in the occipital lobe, and abnormal morphology of the cerebellum. Histopathology included previously unrecognized irregular neuronal migration in the subventricular zone around the lateral ventricles in the frontal lobe and white matter rarefaction especially at the level of the occipital lobe in the cerebrum in addition to the cerebellar cortical dysplasia that has been previously described. The findings of this case may highlight the critical role ofin neurodevelopmental processes in the canine brain.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33244473/