Peer-reviewed veterinary case report
Malignant salivary gland tumor with giant cells in a Boxer dog
By Pérez-Martínez, C et al.·Published in Veterinary pathology·2000·View original on PubMed →
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Original publication title: Malignant fibrous histiocytoma (giant cell type) associated with a malignant mixed tumor in the salivary gland of a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male Boxer was brought to the vet with a large mass in his right jaw area. The mass was found to be made up of two types of cancerous cells, indicating he had both a malignant fibrous histiocytoma (a type of tumor) and a malignant mixed tumor in his salivary gland. The vet diagnosed the tumors based on the appearance of the cells under a microscope. Unfortunately, the outcome of the treatment is not mentioned, but it's important for pet owners to be aware of unusual growths in their pets and seek veterinary care promptly.
People also search for: dog jaw mass · Boxer dog salivary gland tumor · malignant tumor treatment in dogs
Abstract
A 12-year-old male Boxer dog presented with a 5 x 5 x 7-cm partially encapsulated mass in the right mandibular salivary gland. Histologically, the mass was composed of neoplastic epithelial and mesenchymal cells. The mesenchymal component consisted of two cell populations arranged in different patterns: coalescing nodules of neoplastic mononuclear cells with rare osteoid and numerous osteoclastlike giant cells; and sheets of neoplastic spindle cells intermingled with neoplastic epithelial cells and containing osteoid and well-formed bone trabeculae lined by osteoblasts and few osteoclastlike giant cells. On the basis of these histological features, two malignant salivary tumors were diagnosed: a malignant fibrous histiocytoma (giant cell type) and a malignant mixed tumor. Immunohistochemical studies demonstrated keratin 5 and 8 expression by the neoplastic epithelial cells, indicating a probable salivary ductal origin, and vimentin expression by all mesenchymal elements, suggesting a fibroblastic line of differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10896399/