Peer-reviewed veterinary case report
Malignant brain tumor causing seizures and circling in three dogs
By Thio, T et al.·Published in Journal of comparative pathology·2006·Vet-Suisse Faculty·View original on PubMed →
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Original publication title: Malignant histiocytosis of the brain in three dogs.
- Species:
- dog
Plain-English summary
Three dogs, including two Rottweilers and a Flat-coated retriever, showed signs of serious brain problems like depression, circling, and seizures. Sadly, when they were examined after passing away, vets found a solid white mass in the brain and nodules in the lungs, indicating a type of cancer called malignant histiocytosis. This condition involves abnormal growth of certain immune cells and can affect multiple organs. Unfortunately, the prognosis for these dogs was poor due to the aggressive nature of the disease.
People also search for: dog seizures causes · Rottweiler brain tumor symptoms · malignant histiocytosis in dogs
Abstract
Three dogs (two Rottweilers and a Flat-coated retriever) showed various neurological signs, including apathy, depression, circling, a partial decrease in functions associated with cranial nerves, seizures, hyperaesthesia, proprioceptive deficits, and increased spinal reflexes. In all three cases, necropsy revealed a solid, distinct, white mass in the brain and multiple, poorly demarcated, firm nodular proliferations in the lung; in one case the liver was also affected. Histopathological examination showed loosely aggregated, pleomorphic cells, with abundant eosinophilic cytoplasm. The neoplastic cells sometimes contained vacuoles or phagocytized cells. Binucleated and multinucleated giant cells, and mitotic figures, were common. Immunohistochemically, the tumour cells reacted strongly for lysozyme and vimentin, but there was no reaction for S-100 protein, cytokeratin, CD3 or CD79a. The histological and immunohistochemical examinations indicated a histiocytic origin of the tumour cells and malignant histiocytosis was therefore diagnosed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16537081/