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Peer-reviewed veterinary case report

Five dogs, mostly Greyhounds, died after eating hops causing high

By Duncan, K L et al.·Published in Journal of the American Veterinary Medical Association·1997·College of Veterinary Medicine, United States·View original on PubMed

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Original publication title: Malignant hyperthermia-like reaction secondary to ingestion of hops in five dogs.

Species:
dog

Plain-English summary

Five dogs, mostly Greyhounds, became very sick after eating spent hops, which are leftover from brewing beer. About three hours later, they showed serious symptoms like high fever, restlessness, panting, vomiting, stomach pain, and even seizures. Despite emergency treatment, four of the five dogs sadly did not survive, and three showed signs of death very quickly. This situation suggests that hops may trigger a dangerous reaction in some dogs, particularly Greyhounds.

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Abstract

Five dogs, 4 of which were Greyhounds, suffered adverse effects secondary to the ingestion of spent hops. Mean time to onset of clinical signs was 3 hours, and clinical signs included marked hyperthermia, restlessness, panting, vomiting, signs of abdominal pain, and seizures. Four of the 5 dogs died despite aggressive therapeutic measures, and there was rapid onset of rigor mortis in 3. The overrepresentation of Greyhounds, coupled with the clinical signs, was suggestive of a malignant hyperthermia-like response to the ingestion of hops. It also is possible that hops contain an uncoupler of oxidative phosphorylation.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8977648/