Peer-reviewed veterinary case report
Malignant nerve sheath tumor with epithelial cells in a cat
By Rodríguez Guisado, Francisco·Published in Journal of comparative pathology·2024·Institute for Animal Health, Spain·View original on PubMed →
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Original publication title: Malignant peripheral nerve sheath tumour with divergent epithelioid differentiation in a cat.
- Species:
- cat
Plain-English summary
A spayed female Domestic Shorthaired cat, 8 years old, was taken to the vet for a subcutaneous mass on her right side that needed to be surgically removed. After examining the mass, the vet found it was a malignant tumor with unusual cell types. The tumor showed both spindloid and epithelioid cells, which are not commonly seen in cats. This case highlights a rare type of tumor in cats, and while the outcome of the surgery isn't mentioned, early detection and treatment are crucial for managing such conditions.
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Abstract
Divergent differentiation, mainly towards various subsets of mesenchymal cells, is encountered sporadically in human malignant peripheral nerve sheath tumours (MPNSTs) but this is the first report of epithelioid components within this neoplasm in a cat. An 8-year-old, spayed female Domestic Shorthaired cat was presented for surgical removal of a subcutaneous mass on the right flank. Morphological and immunohistochemical analysis revealed a malignant neoplasm with spindloid cells intermixed with an epithelioid component that had squamous differentiation. There was intense immunolabelling of vimentin, S100 protein, neuron-specific enolase, laminin and glial fibrillary acidic protein in the spindloid cell component and for cytokeratin (CK) AE1/AE3 and CK5/6 in the epithelial elements. Melanoma-associated antigen, desmin, α-smooth muscle actin, CD18, CD31, ionized calcium binding adapter molecule-1 and CK8/18 were not expressed, which helped differentiate the tumour from other feline spindloid cell neoplasms. These features are characteristic of divergent epithelioid differentiation of MPNST.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38537328/