Peer-reviewed veterinary case report
Malignant transformation of T-cell leukemia in a Golden Retriever
By Takahashi, Tomoko et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Malignant transformation of T-cell large granular lymphocyte leukemia in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old spayed female Golden Retriever was brought in for mild lymphocyte increase in her blood. Initially, she had a type of leukemia called large granular lymphocyte chronic leukemia, which didn't cause noticeable symptoms for over five months. However, her condition worsened, and she was hospitalized when her blood showed signs of a more aggressive form of leukemia. Despite starting chemotherapy, she sadly passed away a few weeks later, and a necropsy revealed that cancer had spread to her heart, skin, and brain.
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Abstract
An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes. Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chronic leukemia. The dog was subclinical without treatment until hospitalization on day 154, at which point the lymphocytes looked like lymphoblasts and the surface markers changed to CD3-8-. This was regarded as malignant transformation from LGL chronic leukemia to the acute type. Sequential chemotherapy was started, but the dog died on day 190. Necropsy revealed tumor cell infiltration into the heart, skin, and brain.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17611371/