Peer-reviewed veterinary case report
Male cats developed mammary cancer years after hormone injections
By Jacobs, Terry M et al.·Published in Journal of feline medicine and surgery·2010·Park Pet Hospital, United States·View original on PubMed →
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Original publication title: Mammary adenocarcinomas in three male cats exposed to medroxyprogesterone acetate (1990-2006).
- Species:
- cat
Plain-English summary
Three male cats developed multiple mammary tumors after receiving repeated injections of a hormone treatment called medroxyprogesterone acetate (MPA) for issues like aggression and urinating outside the litter box. Over time, these cats had to undergo several surgeries to remove the tumors. This case highlights the risk of male cats developing mammary cancer years after MPA treatment, suggesting that veterinarians should monitor these cats closely for any signs of tumors.
People also search for: male cat mammary tumors · MPA side effects in cats · cat hormone treatment risks
Abstract
In this case series, three unrelated male housemate cats were treated repeatedly with injections of medroxyprogesterone acetate (MPA) for intercat aggression and urinary house soiling. All three cats subsequently developed multiple recurrent mammary adenocarcinomas and underwent numerous surgical resections. This report describes the clinical, histopathological and immunohistochemical findings in these three cats and highlights the potential for mammary carcinomas to develop in male cats years after receiving MPA injections. Extended survival times and a long delay between the administration of the progestin injections and the onset of mammary neoplasia are noted. Estrogen and progesterone receptor staining was performed on some of the tumors and the complex role of hormones in the pathogenesis and the prognosis of feline mammary carcinoma is discussed. Clinicians using MPA should institute life-long surveillance of their feline patients for mammary tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19818661/