Peer-reviewed veterinary case report
Fluorouracil poisoning in a young Labrador-poodle dog and treatment
By Ellis, Heather·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2022·Ontario Veterinary College, Canada·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Management of fluorouracil toxicity in a Labrador retriever-poodle crossbred dog.
- Species:
- dog
Plain-English summary
A young neutered male Labrador retriever-poodle mix was taken to the vet after accidentally ingesting a topical medication containing fluorouracil, which is toxic to dogs. After the exposure, he experienced severe seizures and had to be placed under general anesthesia for control. He spent several days in the hospital in a comatose state but eventually woke up, although he initially had some issues with his vision and sense of smell. Over time, these sensory deficits improved, but he later developed hair loss all over his body. Fortunately, he survived the ordeal and continued to recover.
People also search for: dog fluorouracil poisoning · Labrador retriever seizures treatment · dog hair loss after medication
Abstract
A juvenile, neutered male, Labrador retriever-poodle crossbred dog was brought to a veterinary hospital for overnight care after ingesting fluorouracil 5.0% (5-FU) topical solution. The exposure occurred the night before and involved an unknown amount of fluorouracil. The dog survived the acute toxicity but developed status epilepticus requiring control with general anesthesia and spent multiple days hospitalized in a comatose state, eventually waking with sensory deficits in both vision and smell which resolved over time. Blood samples taken at a recheck visit 1 week after ingestion, showed the dog had developed severe thrombocytopenia and moderate leukopenia. Ten days after initial intoxication, the dog developed progressive alopecia which eventually affected the entire body.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34975172/