Peer-reviewed veterinary case report
Tumor in jaw of rat and horse - what to know
By Murphy, Brian et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2017·Department of Pathology, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Mandibular odontoameloblastoma in a rat and a horse.
- Species:
- horse
Plain-English summary
This study looks at a rare type of tumor called an odontoameloblastoma (OA), which affects the jaw and involves both tooth-forming cells and dental tissue. The researchers describe two cases: one in a 4-month-old rat that was exposed to a harmful substance before birth, and another in a 2-year-old Appaloosa horse. Diagnosing this tumor can be tricky because it shares similarities with other mixed tumors that also involve tooth development. The key to identifying OA is finding specific dental tissue structures within the tumor. The treatment details and outcomes for these cases were not provided in the abstract.
Abstract
Odontoameloblastoma (OA) is a mixed odontogenic tumor that is an ameloblastoma with concurrent histologic evidence of odontoma differentiation. As a mixed tumor, OA is a tripartite lesion comprised of neoplastic odontogenic epithelium, induced dental ectomesenchyme (dental pulp), and mineralized dental matrix. Although rare, OA represents a diagnostic conundrum, as it is histologically closely related to 2 other mixed odontogenic tumors: odontoma (complex and compound) and ameloblastic fibro-odontoma. Herein we describe an OA arising from the mandible of a 4-mo-old Fischer 344 rat that had been exposed in utero to the mutagen ENU (N-ethyl-N-nitrosourea), and a naturally occurring lesion in a 2-y-old Appaloosa horse. In order to satisfy the diagnostic criteria for this lesion, mineralized dental matrix in relationship to neoplastic odontogenic epithelium must be identifiable within the OA lesion. This group of odontogenic tumors is differentiated by the degree to which the dental matrix is organized and the relative proportions of pulp ectomesenchyme, odontogenic matrix, and odontogenic epithelium.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28545325/