Peer-reviewed veterinary case report
Iron metabolism differences in retired racing Greyhounds with bone
By Caro, J T et al.·Published in Veterinary clinical pathology·2013·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Markers of iron metabolism in retired racing Greyhounds with and without osteosarcoma.
- Species:
- dog
Plain-English summary
A group of retired racing Greyhounds, some with osteosarcoma (a type of bone cancer), were studied to understand their iron levels compared to other dogs. The researchers found that the Greyhounds had different iron metabolism, showing lower total iron-binding capacity (TIBC) and higher percent transferrin saturation (%SAT) than non-Greyhounds. Interestingly, both groups of dogs with osteosarcoma had higher serum iron levels than healthy dogs. This suggests that Greyhounds may have unique iron metabolism traits, which could be important for their health management.
People also search for: Greyhound osteosarcoma symptoms · dog iron levels · retired racing Greyhound health issues
Abstract
BACKGROUND: Greyhounds have well-described clinicopathologic idiosyncrasies, including a high prevalence of osteosarcoma (OSA). Hematocrit, HGB, and HGB oxygen affinity are higher than in other dogs, while haptoglobin concentration is lower, so we hypothesized that Greyhounds have a different iron metabolism. To our knowledge, there are no reports on serum iron profiles in Greyhounds. OBJECTIVES: To elucidate iron metabolism in Greyhounds, we wanted to compare serum iron concentration, total iron-binding capacity (TIBC), and percent transferrin saturation (%SAT) in healthy retired racing Greyhounds (RRGs) with OSA (RRGs - OSA), and also with non-Greyhounds (NGs), without and with OSA (NGs - OSA). METHODS: Serum iron concentration and unsaturated iron-binding capacity (UIBC) were measured by standard methods, and TIBC and %SAT were calculated in RRGs (n = 25), RRGs - OSA (n = 28), NGs (n = 30), and NGs - OSA (n = 32). RESULTS: TIBC was lower in RRGs than in NGs (P < .0001), and in RRGs - OSA than in NGs - OSA (P < .0001). NGs - OSA had lower TIBC than healthy NGs (P = .003). Percent SAT was higher in RRGs than in NGs (P < .0001) and in RRGs - OSA (P = .008), and %SAT was also lower in NGs than in NGs - OSA (P = .004). Percent SAT was also higher in RRGs - OSA than in NGs - OSA (P = .001). Both RRGs - OSA (P = .02) and NGs - OSA (P < .0001) had lower serum iron concentrations than their healthy counterparts. CONCLUSION: Lower TIBC and higher %SAT may constitute another Greyhound idiosyncrasy compared with other dogs. In this study, all dogs with OSA had higher serum iron concentrations and %SAT than healthy dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24033801/