Peer-reviewed veterinary case report
Dog develops massive uric acid crystals in urine after lymphoma chemo
By Tvedten, Harold et al.·Published in Veterinary clinical pathology·2019·University Animal Hospital Swedish University of Agricultural Sciences·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Massive uric acid crystalluria and cylinduria in a dog after l-asparaginase treatment for lymphoma.
- Species:
- dog
Plain-English summary
A 10-year-old golden retriever was brought in for diarrhea and vomiting that lasted about a month before being diagnosed with lymphoma. After receiving a chemotherapy treatment called l-asparaginase, the dog's urine became dark yellow and cloudy, showing a large amount of uric acid crystals. Unfortunately, her condition worsened after the treatment, leading to severe protein loss in her urine and low protein levels in her blood. Sadly, the lymphoma treatment was stopped, and the dog was euthanized nine days later due to her declining health.
People also search for: dog lymphoma treatment side effects · golden retriever vomiting and diarrhea · uric acid crystals in dog urine
Abstract
A 10-year-old golden retriever bitch was treated for diarrhea and vomiting that lasted about 1 month without a specific diagnosis until a hepatic biopsy provided a histopathologic diagnosis of lymphoma. The dog was referred to the Swedish University of Agricultural Science and treated with one dose of l-asparaginase. The day after chemotherapy, the urine was dark yellow, very turbid, and had large amounts of small amorphous crystals and many casts made of similar appearing material identified by infrared spectroscopy to be 100% uric acid dihydrate. Serum uric acid was elevated at 224 μmol/L (RI 0-59). The dog's illness became worse after chemotherapy. Lymphoma treatment was not continued, and the dog was euthanized 9 days after the l-asparaginase treatment. Among other problems were persistent proteinuria with a urine protein-to-creatinine ratio of 2.3 and severe hypoalbuminemia. Serum protein electrophoresis performed 3 weeks prior to chemotherapy indicated hyperproteinemia (total protein 78 g/L) having a biclonal gammopathy with 35 g/L β-2 globulins and 11 g/L γ globulins. Despite prominent cylinduria and crystalluria, the patient did not develop azotemia or isosthenuria.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31093999/