Peer-reviewed veterinary case report
Mast cells in dogs with parvovirus intestinal infection
By Woldemeskel, M. W. et al.·Published in Veterinary Pathology·2013·Department of Pathology, College of Veterinary Medicine, Tifton Veterinary Diagnostic and Investigational Laboratory, University of Georgia, Tifton, GA, USA, United States·View original on Crossref →
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Original publication title: Mast Cells in Canine Parvovirus -2–Associated Enteritis With Crypt Abscess
- Species:
- dog
Plain-English summary
A group of dogs with parvovirus infection was studied to see if there were more mast cells (a type of immune cell) in their intestines compared to healthy dogs. The researchers found that dogs with parvovirus-related intestinal issues had significantly more mast cells than healthy dogs, suggesting these cells might play a role in the disease. This study highlights the importance of mast cells in dogs suffering from parvovirus enteritis, which can lead to severe gastrointestinal symptoms. More research is needed to confirm these findings and understand their implications for treatment.
People also search for: dog parvovirus symptoms · mast cells in dog intestines · treatment for dog parvovirus enteritis
Abstract
The role of mast cells (MCs) in allergic reactions and parasitic infections is well established. Their involvement in host immune response against bacterial and viral infections is reported. In this study, investigation is made to determine if MCs are associated with Canine parvovirus-2 (CPV-2)–induced enteritis with crypt abscess (ECA). Mast cell count (MCC) was made on toluidine blue–stained intestinal sections from a total of 34 dogs. These included 16 dogs exhibiting ECA positive for CPV-2 and negative for Canine distemper virus and Canine coronavirus by immunohistochemistry and fluorescent antibody test, 12 dogs with inflammatory bowel disease (IBD), and 6 non-ECA/non-IBD (control) dogs. The average total MCC per high-power field in ECA (40.8 ± 2.2) and IBD (24.7 ± 2.1) was significantly higher ( P < .05) than in the control (3.4 ± 0.6). Although not significant ( P > .05), MCC was also higher in ECA than in IBD. The present study for the first time has documented significantly increased MCs in CPV-2–associated ECA as was previously reported for IBD, showing that MCs may also play an important role in CPV-2–associated ECA. Further studies involving more CPV-infected dogs are recommended to substantiate the findings.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/0300985813485097