Peer-reviewed veterinary case report
How maternally derived antibodies protect puppies from parvovirus
By Decaro, Nicola et al.·Published in Biologicals : journal of the International Association of Biological Standardization·2005·Department of Animal Health and Well-being, Italy·View original on PubMed →
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Original publication title: Maternally-derived antibodies in pups and protection from canine parvovirus infection.
- Species:
- dog
Plain-English summary
A group of puppies with varying levels of maternal antibodies were tested to see how well they could resist canine parvovirus (CPV) infection. Some puppies showed signs of illness even with antibody levels that were thought to be protective. The study found that puppies with certain antibody levels could still get infected, although the infection was less severe and lasted a shorter time compared to those without any antibodies. This suggests that current vaccination guidelines for puppies may need to be updated to better protect them against CPV.
People also search for: puppy parvovirus symptoms · canine parvovirus vaccination guidelines · maternal antibodies in puppies
Abstract
The interaction between maternally-derived antibodies (MDA) and canine parvovirus (CPV) infection was evaluated in five groups of pups with a wide range of haemagglutination inhibiting (HI) titres of MDA (from < 10 to 320). The pups were inoculated with a field CPV strain and monitored daily to evaluate their clinical condition and viral shedding in the faeces. Serum samples were collected weekly to evaluate antibody response. Clinical signs were observed in dogs with HI titres up to 80. Active CPV replication was demonstrated in dogs with HI titres up to 160, although slightly delayed, at lower titres and for a shorter period compared to seronegative dogs. The successful infection of dogs with HI titres of 80 and 160 was also confirmed by seroconversion, evaluated at day 14 postinfection. These findings are in contrast with the MDA titre (HI > or = 80) usually considered fully protective for CPV infection, and suggest the need for revision of current vaccination programmes for pups.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16168665/