Peer-reviewed veterinary case report
Mean platelet size changes in dogs with parvovirus infection
By Engelbrecht, Monique et al.·Published in Frontiers in veterinary science·2021·Department of Companion Animal Clinical Studies·View original on PubMed →
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Original publication title: Mean Platelet Volume and Platelet Volume Distribution Width in Canine Parvoviral Enteritis.
- Species:
- dog
Plain-English summary
A group of 48 dogs with parvovirus infection (CPV enteritis) showed higher levels of platelet activation compared to 18 healthy dogs. The sick dogs had significantly increased mean platelet volume (MPV) and platelet volume distribution width (PVDW), which suggests their bodies were responding to the severe intestinal damage caused by the virus. While the study didn't focus on specific treatments, understanding these platelet changes could help veterinarians assess the severity of the disease and guide treatment decisions. More research is needed to see how these platelet measures might predict outcomes in dogs with parvovirus.
People also search for: dog parvovirus symptoms · dog platelet count normal range · treatment for parvovirus in dogs
Abstract
Bacterial translocation from the damaged intestinal tract, reported in canine parvoviral (CPV) enteritis, is thought to be responsible for the systemic inflammatory response resulting from coliform septicemia, which could ultimately progress to septic shock and death. Alterations in platelet indices, specifically mean platelet volume (MPV), is a consistent finding in critically ill people and dogs with and without sepsis. Increased MPV has been reported to be an indirect indicator of platelet activation and of bone marrow response in people and dogs with sepsis. The study aim was to compare admission MPV and platelet volume distribution width (PVDW) in dogs with CPV enteritis to that of healthy aged-matched control dogs. Forty-eight dogs with CPV enteritis and 18 healthy age matched control dogs were included. CPV infection was confirmed with electron microscopy and concurrent blood-borne infections were excluded using PCR. EDTA whole blood samples were analyzed on an automated cell counter, ADVIA 2120, within 30-60 min from collection. There was no significant difference for platelet count between the groups. The MPV for CPV infected dogs (median: 14.0;: 12.2-15.1) was significantly higher compared to controls (11.3;: 10.3-13.1,= 0.002). The PVDW for CPV infected dogs (66.9;: 64.2-68.8) was significantly higher compared to controls (63.3;: 60.2-65.1,<). These findings suggest that significant platelet activation is present in dogs with CPV enteritis which may play a role in the disease outcome, similar to people with sepsis. Further studies are required to investigate the prognosticating ability of MPV in dogs with CPV enteritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34692806/