Peer-reviewed veterinary case report
How long do carbomer eye gels last on dog eyes under anesthesia
By Michaud, Bertrand et al.·Published in Veterinary ophthalmology·2026·Clinique Vé, France·View original on PubMed →
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Original publication title: Measurement of the Retention Time of Two Different Carbomer-Based Ophthalmic Gels With and Without Hyaluronic Acid in Anesthetized Dogs Using Ultrahigh-Resolution Optical Coherence Tomography.
- Species:
- dog
Plain-English summary
A group of healthy dogs under anesthesia had two different eye gels applied—one with just carbomer and the other with carbomer plus sodium hyaluronate. The gel with sodium hyaluronate (Eye Lube Pro) stayed on the eye longer and provided better moisture retention compared to the other gel (Ocry-gel). After an hour, 14 out of 20 dogs still had measurable moisture from Eye Lube Pro, while only 2 dogs had moisture from Ocry-gel. This suggests that the gel with sodium hyaluronate may be a better choice for protecting the eyes during longer procedures.
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Abstract
PURPOSE: To evaluate the stability of two ophthalmic gels-one containing carbomer alone (Ocry-gel), and the other combining carbomer with sodium hyaluronate (Eye Lube Pro)-on the corneal surface of anesthetized dogs, using spectral-domain optical coherence tomography (SD-OCT) to quantify Central Tear Film Thickness (CTFT) over time. MATERIALS AND METHODS: Twenty healthy dogs undergoing general anesthesia for non-ocular routine procedures were included in a randomized controlled study. Each dog received Ocry-gel in one eye and Eye Lube Pro in the contralateral eye, according to a randomization protocol. CTFT was measured with ultrahigh-resolution anterior segment SD-OCT before (T0) and after (T1) administration of 200 μL of each gel, then at 10, 15, 20, 25, 30, 35, 40, 45, 50, and 60 min. CTFT evolution was analyzed by two-way repeated-measures ANOVA with normality testing and non-parametric correction when required. RESULTS: CTFT profiles significantly differed between formulations. Eye Lube Pro exhibited more sustained thickness than Ocry-gel. After 60 min, CTFT remained measurable in 14/20 dogs for Eye Lube Pro versus 2/20 for Ocry-gel. Statistical analysis confirmed significantly higher CTFT for Eye Lube Pro at most time points (p < 0.001). No significant influence of sex, age, or brachycephalic phenotype was observed. CONCLUSIONS: Addition of sodium hyaluronate to a carbomer-based gel significantly prolongs pre-corneal retention time in anesthetized dogs. These results suggest that selecting the protective gel should consider anesthesia duration or guide adjustment of administration frequency.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41190628/