Peer-reviewed veterinary case report
Tumor low oxygen measured in dogs with spontaneous sarcomas
By Bruehlmeier, Matthias et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2005·Vetsuisse Faculty·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Measurement of tumor hypoxia in spontaneous canine sarcomas.
- Species:
- dog
Plain-English summary
A group of six dogs with spontaneous sarcomas (a type of cancer) underwent special imaging tests to check for low oxygen levels in their tumors. The tests showed that three of the dogs had hypoxic tumors, meaning these tumors weren't getting enough oxygen, which can affect treatment outcomes. The imaging results were confirmed by direct measurements taken from the tumors. Understanding tumor oxygen levels can help veterinarians decide on the best treatment options for dogs with these types of cancers.
People also search for: dog cancer treatment options · signs of sarcoma in dogs · canine tumor oxygen levels
Abstract
We used positron emission tomography (PET) with [18F]fluoromisonidazole ([18F]FMISO) to study tumor hypoxia in six dogs with spontaneous sarcomas. The tumors were regarded as hypoxic if [18F]FMISO uptake exceeded normal tissue radioactivity by 40% (tumor/muscle ratio > 1.4) or if kinetic analysis indicated a positive [18F]FMISO tissue influx rate (Ki > 0) by a Patlak plot. Using these criteria, we found hypoxia in a fibrosarcoma grade II, an undifferentiated sarcoma, and an ostoeosarcoma, but not in a fibrosarcoma grade I, another osteosarcoma, and a myxosarcoma. In three animals, the tumor oxygen partial pressure (pO2) was also measured invasively using Eppendorf needle electrodes. In these cases, the Eppendorf measurements were confirmed by the [18F]FMISO PET results. In addition, [15O]H2O PET was performed in four dogs in order to assess tumor perfusion. Comparisons of the [18F]FMISO with [15O]H2O PET images in two cases showed that tumor hypoxia occurred in the tumor center with low perfusion, whereas perfusion was heterogeneous in a nonhypoxic tumor.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16229439/