Peer-reviewed veterinary case report
CRP and NGF levels in dogs with nerve and bladder problems
By Kordass, Ulrike et al.Ā·Published in BMC veterinary researchĀ·2016Ā·Department of Small Animal Medicine and Surgery, GermanyĀ·View original on PubMed ā
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Original publication title: Measurements of C-reactive protein (CRP) and nerve-growth-factor (NGF) concentrations in serum and urine samples of dogs with neurologic disorders.
- Species:
- dog
Plain-English summary
A group of dogs with neurological disorders, including issues with urination, were tested for certain proteins in their blood and urine to see if they could help identify the cause of their problems. The study found that while levels of C-reactive protein (CRP) were higher in dogs with urination issues, neither CRP nor nerve growth factor (NGF) proved to be reliable indicators for diagnosing these conditions. This means that while these proteins might be involved in the problems, they can't be used alone to determine the cause of urination difficulties in dogs with spinal cord issues.
People also search for: dog urination problems Ā· dog spinal cord disease symptoms Ā· CRP levels in dogs
Abstract
BACKGROUND: The purpose of this study was to prove the hypothesis that C-reactive protein (CRP) and nerve growth factor (NGF) may be potential biomarkers for lower urinary tract disorders and may be able to distinguish between micturition dysfunctions of different origin in dogs with spinal cord diseases. NGF- and CRP- concentrations were measured in serum and urine samples using specific ELISA-Kits. Results in urine were standardized by urine-creatinine levels. RESULTS: CRP in serum was detectable in 32/76 and in urine samples in 40/76 patients. NGF could be measured in all serum and in 70/76 urine samples. Urinary CRP concentrations were significantly higher in dogs with micturition dysfunction (p = 0.0009) and in dogs with different neurological diseases (p = 0.0020) compared to the control group. However, comparing dogs with spinal cord disorders with and without associated micturition dysfunction no significant difference could be detected for NGF and CRP values in urine or serum samples. Additionally, levels did not decrease significantly, when measured at the time when the dogs regained the ability to urinate properly (urinary NGF p = 0.7962; urinary CRP p = 0.078). Urine samples with bacteria and/or leukocytes had no significant increase in urinary NGF (p = 0.1112) or CRP (p = 0.0534) concentrations, but higher CRP-levels in urine from dogs with cystitis were found compared to dogs without signs of cystitis. CONCLUSIONS: From these data we conclude that neither CRP nor NGF in urine or serum can be considered as reliable biomarkers for micturition disorders in dogs with spinal cord disorders in a clinical setting, but their production might be part of the pathogenesis of such disorders. Significantly higher levels of CRP could be found in the urine of dogs with micturition dysfunctions compared to control dogs. This phenomenon could potentially be explained by unspecific extrahepatic CRP production by smooth muscle cells in the dilated bladder.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26746899/