Peer-reviewed veterinary case report
Treatment with mechlorethamine, procarbazine, and prednisone
By Northrup, N C et al.·Published in Veterinary and comparative oncology·2009·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs.
- Species:
- dog
Plain-English summary
A group of 41 dogs with resistant lymphoma (a type of cancer) was treated with a combination of medications called MPP, which includes mechlorethamine, procarbazine, and prednisone. About 34% of the dogs responded to this treatment, with some experiencing complete remission lasting up to 238 days. The dogs showed minimal side effects, indicating that the treatment was well-tolerated. This suggests that there may be options for more aggressive treatment in the future if needed.
People also search for: dog lymphoma treatment · resistant lymphoma in dogs · mechlorethamine for dogs · prednisone for dog cancer · dog cancer survival rates
Abstract
Forty-one dogs with resistant lymphoma were treated with a modified MOPP (mechlorethamine, vincristine, procarbazine and prednisone) protocol (MPP [mechlorethamine, procarbazine and prednisone] administered on a 21-day cycle, shortened from the 28-day MOPP cycle). The overall response rate to MPP was 34% for a median of 56 days (95% confidence interval 30-238). Seventeen percent of dogs had a complete response for a median duration of 238 days, 17% had a partial response for a median of 56 days and 32% had stable disease for a median of 24 days. Histological grade or cell morphology on cytology was associated with response. Minimal toxicity was observed with the MPP protocol, suggesting that further dose intensification or addition of another chemotherapeutic agent would be possible.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19222829/