Peer-reviewed veterinary case report
Treatment results for relapsed lymphoma in dogs using MOMP protocol
By Back, A R et al.·Published in Veterinary and comparative oncology·2015·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Mechlorethamine, vincristine, melphalan and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs.
- Species:
- dog
Plain-English summary
A group of 88 dogs with relapsed lymphoma were treated using a combination of medications known as MOMP (mechlorethamine, vincristine, melphalan, and prednisone) over a 28-day cycle. About 51% of the dogs responded to the treatment, with some experiencing complete remission for an average of 81 days and others showing partial improvement for around 49 days. The treatment was generally well-tolerated, with most side effects being mild. Overall, the dogs had an average survival time of about 183 days after starting the treatment, making MOMP a viable option for managing relapsed lymphoma in dogs.
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Abstract
Eighty-eight dogs with relapsed lymphoma were treated with the MOMP (mechlorethamine, vincristine, melphalan and prednisone) protocol on a 28-day treatment cycle. The overall response rate (ORR) to the MOMP protocol was 51.1% for a median of 56 days (range 7-858 days). Twelve percent of dogs experienced a complete response for a median of 81 days (range 42-274 days) and 38.6% experienced a partial response for a median of 49 days (range 7-858 days). Dogs with T-cell lymphoma had an ORR of 55% for a median of 60 days (range 49-858 days) while those with B-cell lymphoma had an ORR of 57% for a median of 81 days (range 7-274 days) (P = 0.783). The overall survival time for all dogs was 183 days (range 17-974 days). Fifty-four percent of dogs experienced toxicity with the majority classified as grade I. The MOMP protocol seems well-tolerated and is an option for dogs with relapsed lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23910023/