Peer-reviewed veterinary case report
Treatment of feline injection site sarcoma using masitinib medication
By J. Ledoux et al.·Published in Veterinary medicine·2014·View original on Semantic Scholar →
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Original publication title: Medical approach to the treatment of feline injection site sarcoma with masitinib: a case report
- Species:
- cat
Plain-English summary
A cat with an injection site sarcoma, a type of tumor that can develop at vaccination sites, was treated with a medication called masitinib. This drug, which is typically used for treating mast cell tumors in dogs, initially helped shrink the tumor, but it later came back. However, the tumor was stabilized and showed some reduction in size with continued treatment. This case suggests that masitinib might be a useful option for managing this challenging condition in cats, especially when surgery isn't possible.
People also search for: cat injection site sarcoma treatment · masitinib for cat tumors · feline cancer medication options
Abstract
Abstract Feline injection site sarcoma is a common tumor among cats, for which existing medical treatments do not prove to be entirely satisfactory. In this tumor, the platelet-derived growth factor receptor, a tyrosine kinase receptor, is frequently hyperactivated. In the past, clinical case reports with imatinib, a tyrosine kinase inhibitor (TKI), have demonstrated tumoral stabilization. Here we describe the use of another TKI, masitinib, which specifically inhibits c-Kit, platelet-derived growth factor receptor, and Lyn, and is currently licensed for veterinary use in canine mast cell tumors. The therapeutic results were initially satisfactory, with regression of the tumor followed by tumoral recurrence which was stabilized and moderately reduced. Further studies are suggested, in order to evaluate the relevance of TKIs in the treatment and prevention of recurrences of feline injection site sarcoma. Tumoral stabilization by means of an inexpensive and reasonably well tolerated treatment would prove to be of true therapeutic relevance, in particular for inoperable feline injection site sarcomas. Another indication for such TKIs could be in preoperative treatment as a means of facilitating surgical excision by reduction of adhesions.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/32670851