Peer-reviewed veterinary case report
Kidney disease linked to too many vaccines in young cocker spaniel
By Ortloff, A et al.·Published in The Journal of small animal practice·2010·College of Veterinary Medicine·View original on PubMed →
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Original publication title: Membranoproliferative glomerulonephritis possibly associated with over-vaccination in a cocker spaniel.
- Species:
- dog
Plain-English summary
A 7-month-old male cocker spaniel was diagnosed with a serious kidney problem called membranoproliferative glomerulonephritis after the owner vaccinated him seven times in just seven months without veterinary guidance. The dog's symptoms included kidney issues, but tests ruled out cancer and infections. Doctors found that the dog's kidneys had thickened walls and deposits linked to the vaccines. This case suggests that too many vaccinations in a short time may have led to the dog's kidney disease. Treatment details weren't specified, but it's important for pet owners to follow vaccination schedules recommended by veterinarians.
People also search for: cocker spaniel kidney disease · dog vaccination schedule · symptoms of kidney problems in dogs
Abstract
Membranoproliferative glomerulonephritis was observed in a seven-month-old male cocker spaniel dog. The clinical, microbiological, biochemical, radiographic and ultrasonographic examinations ruled out neoplasia, congenital disease and infectious disease. The anamnesis revealed that the owner had vaccinated the dog seven times, one vaccination per month, without veterinarian supervision. In both kidneys, severe thickening of the glomerular capillary walls was observed. Electron microscope examination revealed a large number of electron-dense deposits that were primarily in the glomerular subendothelial spaces and the basal membrane, which is compatible with antigen-antibody complexes. The immunohistochemical examination revealed that the antigen present in the glomeruli corresponded with the antigen present in the vaccine. We report a type III hypersensitivity nephropathy in a young dog, which was possibly caused by over-vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21050219/