Peer-reviewed veterinary case report
Kidney disease linked to Leishmania and heartworm in a German
By Aresu, Luca et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2007·Dipartimento di Patologia Animale, Italy·View original on PubMed →
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Original publication title: Membranoproliferative glomerulonephritis type III in a simultaneous infection of Leishmania infantum and Dirofilaria immitis in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old female German Shepherd was diagnosed with kidney disease after showing symptoms related to a serious infection. The dog had membranoproliferative glomerulonephritis (a type of kidney inflammation) linked to infections from Leishmania and heartworm (Dirofilaria immitis). Tests showed significant changes in her kidney structure, indicating severe damage. Treatment details are not provided, but managing these infections is crucial for improving kidney function.
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Abstract
In this report a 9-year-old female German Shepherd dog with a membranoproliferative glomerulonephritis (MPGN) type III associated with concomitant infection of Dirofilaria immitis and Leishmania infantum is presented. Light microscopic evaluation of kidney revealed a diffuse hypercellularity and thickening of glomerular basement membrane. Heavy and coarse granular complement C(3) deposition and a weaker positive reaction to immunoglobulin G were present along peripheral glomerular basement membrane and in the mesangium in the immunofluorescent study. Transmission electron microscopy revealed deposits in the mesangium, subendothelium, and subepithelium. These lesions are compatible with membranoproliferative glomerulonephritis type III in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17823406/