Peer-reviewed veterinary case report
Dog with black toe tumor spreading to lungs and organs
By da Silva, Laice A et al.·Published in Journal of comparative pathology·2022·Department of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Metastatic Digital Chondrogenic Melanocytic Tumour in a Dog.
- Species:
- dog
Plain-English summary
A 9-year-old Brazilian Mastiff was brought in with severe swelling in all four legs and difficulty moving, which had been worsening over the past year. Unfortunately, despite medical treatment, the dog did not improve and was euthanized. A growth was found on the dog's toe, and further examination revealed that the cancer had spread to various organs, including the lungs and kidneys. This case highlights a rare type of cancer that affected the dog's limbs and other parts of the body, ultimately leading to a poor outcome.
People also search for: dog leg swelling · Brazilian Mastiff cancer symptoms · metastatic tumor in dogs treatment
Abstract
A 9-year-old intact male Brazilian Mastiff dog with a 1-year history of progressive severe swelling in all four limbs and significant locomotory difficulty was euthanized due to unresponsiveness to medical management. Macroscopically, the distal phalanx of the 5digit of the left hindlimb was replaced by a cutaneous, non-ulcerated, 3.0 cm diameter, multilobulated, black, firm nodule. The cortical bones of the appendicular skeleton were thickened and partially effaced by infiltrative coalescing nodules (0.1-1.0 cm diameter). The lungs, heart, pleura, mesentery, adrenal glands and kidneys were infiltrated by similar nodules (0.5-3.5 cm diameter). Histological evaluation of the masses revealed a non-encapsulated malignant neoplasm composed of spindloid to polygonal cells that contained variable amounts of intracytoplasmic melanin and were arranged in haphazardly interlacing streams and bundles supported by scant fibrovascular stroma with myxoid and chondroid matrix formation. Neoplastic cells had intense cytoplasmic labeling for S100 and 10% had moderate cytoplasmic immunoreactivity for Melan-A. To the authors' knowledge, this is the first description of a canine metastatic digital chondrogenic melanocytic tumour with strongly suggestive chondroid differentiation of neoplastic melanocytes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35152967/