Peer-reviewed veterinary case report
Dog with perianal gland tumor that spread to lymph nodes
By McCourt, Maggie R et al.·Published in Veterinary clinical pathology·2018·Department of Veterinary Pathobiology·View original on PubMed →
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Original publication title: Metastatic disease in a dog with a well-differentiated perianal gland tumor.
- Species:
- dog
Plain-English summary
An 8-year-old male Miniature Poodle was brought in for straining to defecate (tenesmus) and was found to have a tumor near the anus. Although the tumor appeared benign under the microscope, further tests showed that it had spread to nearby lymph nodes, indicating it was actually a malignant perianal gland tumor (adenocarcinoma). The dog underwent surgery to remove the tumor, and the findings confirmed the diagnosis. This case emphasizes that even tumors that look harmless can behave aggressively, so it's important for pet owners to follow up on any unusual growths.
People also search for: dog perianal tumor treatment · Miniature Poodle cancer symptoms · why is my dog straining to poop
Abstract
Fine-needle aspirates from a perianal mass on an 8-year-old, intact male, Miniature Poodle presenting for tenesmus showed a uniform population of well-differentiated hepatoid cells with no notable criteria of malignancy. The cytologic diagnosis was a perianal gland tumor, with adenoma likely given the cytomorphology. The abdominal ultrasound revealed multiple, markedly enlarged, intra-abdominal lymph nodes. LN aspirates also showed well-differentiated polygonal, hepatoid cells displaying no notable cellular atypia. The presence of the metastasis led to the interpretation of a well-differentiated, malignant perianal gland tumor despite the benign cellular appearance. Histopathology of the surgically excised perianal mass and one enlarged abdominal lymph node revealed lobules of uniform polygonal hepatoid cells arranged in organized islands and trabeculae surrounded by a single layer of uniform reserve cells. Few mitotic figures were present. The only histopathologic indication of malignancy within the primary mass was the presence of small islands of well-differentiated hepatoid cells infiltrating into adjacent tissue and possible lymphatic invasion. The histopathologic diagnosis was perianal gland adenocarcinoma. Most textbooks describe perianal gland adenocarcinomas as showing increased cellular atypia including pleomorphism, disorganization of hepatoid cells, and increased numbers of pleomorphic reserve cells with mitotic figures. This case is an example of the occurrence of a well-differentiated perianal gland tumor with metastasis and highlights the importance of realizing that with these tumors, a benign cytologic and histologic appearance may not correlate with biologic behavior. To the authors' knowledge, this is the first case reporting both the cytologic and histologic appearance of a well-differentiated metastatic hepatoid gland tumor.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30347120/