Peer-reviewed veterinary case report
Metastatic extra-adrenal sympathetic paraganglioma in a horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2010
- Authors:
- Herbach, N et al.
- Affiliation:
- Institute of Veterinary Pathology · Germany
- Species:
- horse
Plain-English summary
A horse that showed signs of colic, which is abdominal pain, unfortunately passed away. After the horse died, a thorough examination revealed a large, round mass in the abdomen near the left kidney, along with bleeding in the abdominal cavity. The mass was solid and dark red to brown, and there were smaller nodules around it. Additionally, the spleen was firm, and there were nodules found in one of the thyroid glands. The examination showed that the mass and nodules contained abnormal cells, indicating a type of cancer called metastatic extra-adrenal sympathetic paraganglioma.
Abstract
Post-mortem examination was performed on a horse that died after exhibiting signs of colic. Gross findings included haemoperitoneum and a large round encapsulated mass located in the sublumbar area cranial to the left kidney. On sectioning the mass was solid red to brown and small nodules of similar tissue were noted at the periphery of the mass. The spleen was firm and three nodules were found in one thyroid gland. Microscopically, the abdominal mass, adjacent nodules, the spleen and one thyroid nodule consisted of clusters and cords of round to oval neoplastic cells, separated by a fine collagen and reticulin fibre network. Immunohistochemically, tumour cells expressed chromogranin A, synaptophysin and neuron-specific enolase, but did not express cytokeratin. The findings were consistent with a metastatic extra-adrenal sympathetic paraganglioma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20153870/