Peer-reviewed veterinary case report
Metastatic lymphangiosarcoma in a horse.
- Journal:
- Veterinary pathology
- Year:
- 2002
- Authors:
- Sanchez, B et al.
- Affiliation:
- Departamento de Patologia Animal II · Spain
- Species:
- horse
Plain-English summary
A horse was diagnosed with a type of cancer called lymphangiosarcoma, which had spread to other parts of the body. The horse showed signs of trouble breathing and swelling in its chest and belly. A thorough examination after the horse passed away revealed that many lymph nodes were swollen and had areas of dead tissue. The cancer was also found in the spleen, lungs, and kidneys, and tests on the tumor cells showed specific markers that indicated the type of cancer present. Unfortunately, the findings suggest that the cancer was quite advanced and likely not treatable.
Abstract
A lymphangiosarcoma with metastases was found in a horse that presented with respiratory distress and edema in the ventral thorax and abdomen. The necropsy revealed diffuse edema in the subcutaneous connective tissue. Mediastinal, mesenteric, iliac, and renal lymph nodes were enlarged and white with soft, yellowish necrotic areas. Histologic examination revealed numerous channels and disorganized vessels lined by large polyhedral, polymorphic cells. Tumor metastases were observed in the spleen, lungs, and kidneys. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for factor VIII, vimentin, and keratin. Laminin was scarce, and collagen IV staining was negative, consistent with a discontinuous or absent basement membrane.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12009065/