Peer-reviewed veterinary case report
Metronomic chemotherapy for treating malignant oral tumors in dogs
By Milevoj, Nina et al.·Published in Frontiers in veterinary science·2022·Small Animal Clinic·View original on PubMed →
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Original publication title: Metronomic Chemotherapy for Palliative Treatment of Malignant Oral Tumors in Dogs.
- Species:
- dog
Plain-English summary
A group of dogs with malignant oral tumors received metronomic chemotherapy using cyclophosphamide to help manage their condition. About half of the dogs showed some improvement in their symptoms one month after starting treatment, and a third continued to benefit after three months. The average survival time for these dogs was about 155 days, though most experienced disease progression by the end of the study. Some dogs did have side effects, with a few developing sterile hemorrhagic cystitis, which is inflammation of the bladder. Overall, this treatment may help some dogs feel better during their illness.
People also search for: dog oral tumor treatment · metronomic chemotherapy for dogs · side effects of cyclophosphamide in dogs
Abstract
The aim of this study was to evaluate the efficacy of metronomic chemotherapy in the palliative treatment of various malignant oral tumors in dogs. Our focus was to determine the effect of treatment on local disease control and to assess the tolerability and safety of the treatment in dogs with various oral malignancies. Metronomic chemotherapy with cyclophosphamide was used to treat 12 dogs and was combined with non-steroidal anti-inflammatory drugs in 6/12 (50%) of dogs. A clinical benefit was observed in 6/12 (50%) patients 1 month and in 4/12 (33%) 3 months after treatment initiation. The median survival time of the dogs was 155 days (range 21-529 days). At the end of the observation period, the disease had progressed in 10/12 (83.3%) of the patients. Sterile hemorrhagic cystitis was the most commonly reported side effect of treatment, occurring in 4/12 (33.3%) dogs. The results of our study suggest that metronomic chemotherapy with cyclophosphamide can be, in a subset of dogs, beneficial in the palliation of malignant oral tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35433894/